HDAC-IN-55(8j) is a small molecular compound that can increase the expression of E-cadherin and inhibit the proliferation of cancer cells[1].
HDAC-IN-55(8j) 作用于SW620 细胞系和 H520 细胞系的 EC50 值分别是 4.47 和 1.61 μM[1]。
HDAC-IN-55(8j) (10 μM, 24 h) 可以使 SW620 细胞中的 E-钙粘蛋白表达增加，并抑制 SW620 细胞增殖[1]。
[1]. Sydney L Stoops, et al. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol. 2011 May 20;6(5):452-65.