HBP08 is a peptide inhibitor of the protein-protein interaction between chemokine (C-X-C motif) ligand 12 (CXCL12) and high mobility group protein B1 (HMGB1).[1] It binds to HMGB1 (Kd = 0.8 µM) and inhibits HMGB1-induced inhibition of CXCL12-induced migration of 300-19 pre-B cells expressing human chemokine (C-X-C motif) receptor 4 (CXCR4).
References:
[1].Sgrignani, J., Cecchinato, V., Fassi, E.M.A., et al.Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interactionJ. Med. Chem.64(18)13439-13450(2021).