Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone.
Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1].
After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability[1].
Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1].
References:
[1]. Faïza Taïbi, et al. Effect of ecdysone agonist RH-0345 on reproduction of mealworm, Tenebrio molitor. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):257-67.