HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier[1].
HAIYPRH hydrochloride (T7) is conjugated to liposomes for ischemic stroke targeting treatment of a novel neuroprotectant [2].
HAIYPRH hydrochloride is a heptapeptide that can be used to target gliomas[3].
HAIYPRH hydrochloride, a transferrin receptor-specific peptide, is chosen as the ligand to target the co-delivery system to the tumor cells expressing transferrin receptors. HAIYPRH-modified co-delivery system shows higher efficiency in cellular uptake and gene expression than unmodified co-delivery system in U87 MG cells, and accumulated in tumor more efficiently in vivo[1].