Gymnemic acid I is a triterpene glycoside that has been found in G. sylvestre and has antihyperglycemic activities.1,2 It inhibits glucose-induced phosphorylation of serine 70 on S6 kinase (S6K1) and serine 2448 on mTOR, caspase-3 activity, and apoptosis, as well as increases autophagy in MIN-6 pancreatic β cells when used at a concentration of 5 μg/ml.1 Gymnemic acid I has been used as a reference compound to compare the potency of plant-derived sweet taste inhibitors.2
|1. Wu, Y., Hu, Y., Yuan, Y., et al. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress. J. Cell. Physiol. 234(6), 9370-9377 (2019).