Guanine-15N5 is intended for use as an internal standard for the quantification of guanine by GC- or LC-MS. Guanine is a purine base.[1] It forms complementary base pairs with the pyrimidine cytosine in DNA and RNA. Guanine can be linked to ribose via a β-N9-glycosidic bond to form the purine nucleoside guanosine , which can be phosphorylated to guanine-based purines that have numerous roles in intracellular signal transduction.2,3
References:
[1].Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002).
[2].Devereaux, Z.J., He, C.C., Zhu, Y., et al.Structures and relative glycosidic bond stabilities of protonated 2'-fluoro-substituted purine nucleosidesJ. Am. Soc. Mass Spectrom.30(8)1521-1536(2019).
[3].Di Liberto, V., Mudò, G., Garozzo, R., et al.The guanine-based purinergic system: The tale of an orphan neuromodulationFront. Pharmacol.7158(2016).