Glyphosine is an organophosphate plant growth regulator.1 It decreases chlorophyll production in new fronds of L. gibba when used at a concentration of 500 µM.1 Glyphosine has been used as a sugarcane ripener.2 It also increases the T cell response to an insulin B chain autoantigenic peptide corresponding to amino acids 9-23 of human insulin (EC50 = 70.6 nM) and delays the onset of diabetes in non-obese diabetic (NOD) mice when administered at a dose of 80 mg/kg per day.3
1.Slovin, J.P., and Tobin, E.M.Glyphosine, a plant growth regulator, affects chloroplast membrane proteinsBiochim. Biophys. Acta637(1)177-184(1981) 2.Samuels, G., and VÉlez-Ramos, A.Field experiments with Polaris as a chemical ripener of sugarcane in Puerto Rico, 1971-72J. Agr. U. Puerto Rico61(2)242-249(1977) 3.Michels, A.W., D.A., O., Zhang, L., et al.Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationJ. Immunol.187(11)5921-5930(2011)