Glycine-13C is intended for use as an internal standard for the quantification of glycine by GC- or LC-MS. Glycine is a conditionally essential amino acid and the major inhibitory neurotransmitter in the spinal cord and brainstem.1,2 It is synthesized from threonine, choline, hydroxyproline, and serine via interorgan metabolism between the liver and kidneys.2 It can also be derived from dietary sources. Glycine is essential to protein synthesis and the conjugation of bile acids and is a precursor in glutathione, purine, heme, and serine synthesis.
1.Zafra, F., AragÓn, C., Olivares, L., et al.Glycine transporters are differentially expressed among CNS cellsJ. Neurosci.15(5 Pt 2)3952-3969(1995) 2.Wang, W., Wu, Z., Dai, Z., et al.Glycine metabolism in animals and humans: Implications for nutrition and healthAmino Acids45(3)463-477(2013)