(Gly14)-Humanin (human) (acetate)

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions.

(Gly14)-Humanin (human) acetate (0.1-10 μM; 72 hours) significantly increases cell viability, reduced nuclear fluorescence of HUVECs, the levels of cleaved PARP, ROS formation and the ratio of bax/bcl-2 compared with treatment with high glucose (HG) for 72h. And reduces mRNA level of bax and increases mRNA level of bcl-2^[1].

(Gly14)-Humanin (human) acetate acetate (0.1 μg/5 μL; i.c.v.; once) decreases cells with plasmalemma permeability in the injured cortex and hippocampus, reduces brain lesion volume, improves motor performance and ameliorates performance in the Morris water maze test^[2].

References:
[1]. Ying Xie, et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6.
[2]. T Wang, et al. [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 2013 Feb 12;231:70-81.