GlpBio

Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)

目录号: GC92133纯度: >98.00%同义词: Gastric Inhibitory Peptide (1-42); GIP (1-42)
Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)是一种内源性42个氨基酸的肽肠促胰岛素激素，可诱导胰岛素分泌。
Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥840.00现货
1
5 mg¥3,122.00现货
1
10 mg¥5,810.00现货
1
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产品描述 Description

Glucose-dependent Insulinotropic Polypeptide (GIP) (1-42) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion.1,2 It is expressed in intestinal neuroendocrine K cells and the submandibular gland and is released into circulation postprandially. GIP (1-42) inhibits histamine, pentagastrin, and insulin-induced gastric acid and pepsin secretion, increases glucose-induced insulin release, and stimulates gastric emptying in rats.3

References:
[1]. Fehmann, H.-C., and G?ke, B.Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcriptionPeptides16(6)1149-1152(1995).
[2]. Siskos, A.P., Katsila, T., Balafas, E., et al.Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: Preclinical evaluation of DP-IV inhibitorsJ. Proteome Res.8(7)3487-3496(2009).
[3]. Rossowski, W.J., Zacharia, S., Mungan, Z., et al.Reduced gastric acid inhibitory effect of a pGIP(1-30)NH2 fragment with potent pancreatic amylase inhibitory activityRegul. Pept.39(1)9-17(1992).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

同义词
Gastric Inhibitory Peptide (1-42); GIP (1-42)
化学名
L-tyrosyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-α-aspartyl-L-lysyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysylglycyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparaginyl-L-isoleucyl-L-threonylL-tyrosyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-α-aspartyl-L-lysyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysylglycyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparaginyl-L-isoleucyl-L-threonyl-L-glutamine, trifluoroacetate salt
SMILES
O=C(N[C@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CO)C(N[C@@](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](CCCCN[H])C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(N)=O)C(N[C@@](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)CC8=CC=CC=C8)=O)=O)=O)=O)C)[C@H](CC9=CC=C(O)C=C9)N[H].OC(C(F)(F)F)=O
分子式
C225H342N60O66S ? XCF3COOH
分子量
4975.6 g/mol
溶解性
Water: Soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol