Gloxazone is an effective and toxic anaplasmacide[1]. Gloxazone has been widely used in the study of the immune responses of different animals to Cowdria ruminantium[2].
In vivo, Gloxazone treatment (10mg/kg/day; s.c.) for 14 days alleviated the parasitaemia in the steers and calves artificially infected with Anaplasma marginale[4]. Treatment with Gloxazone (i.v.) at a dose of 5mg/kg/day for 11days can alleviate the heartwater symptoms caused by infection with Cowdria within Balb/C mice[5].
References:
[1] McHardy N, Berger J, Taylor R J, et al. Comparison of gloxazone, an effective but toxic anaplasmacide, with imidocarb dihydrochloride[J]. Research in Veterinary Science, 1980, 29(2): 198-202.
[2] Todorovic R A, Lopez L A, Lopez A G, et al. Bovine babesiosis and anaplasmosis: Control by premunition and chemoprophylaxis[J]. Experimental parasitology, 1975, 37(1): 92-104.
[3] Kuttler K L. Current anaplasmosis control techniques in the United States[J]. Journal of the South African Veterinary Association, 1979, 50(4): 314-320.
[4] McHardy N. Serological responses to bovine anaplasmosis following treatment with gloxazone[J]. Veterinary Parasitology, 1980, 7(4): 287-296.
[5] McHardy N, Mackenzie P K. Virulence of two strains of Cowdria ruminantium in mice and their use to predict drug activity against heartwater[J]. Tropical Animal Health and Production, 1984, 16(1): 56-62.
Gloxazone是一种高效但具毒性的anaplasmacide[1]。Gloxazone广泛用于研究不同动物对Cowdria ruminantium的免疫反应[2-3]。
在体内，人工感染Anaplasma marginale的阉牛和犊牛经Gloxazone（10mg/kg/day；皮下注射）连续治疗14天后，寄生虫血症症状得到缓解[4]。静脉注射Gloxazone（5mg/kg/day）治疗11天，可减轻Balb/C小鼠因Cowdria感染引发的心水病临床症状[5]。