Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach.1 It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.2 It is a peptide of 28 amino acids, in which the serine 3 residue is n-
1.Kojima, M., Hosoda, H., Date, Y., et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomachNature402(6762)656-660(1999) 2.Murphy, K.G., and Bloom, S.R.Gut hormones in the control of appetiteExp. Physiol.89(5)507-516(2004) 3.Gutierrez, J.A., Solenberg, P.J., Perkins, D.R., et al.Ghrelin octanoylation mediated by an orphan lipid transferaseProc. Natl. Acad. Sci. USA105(17)6320-6325(2008)
















