Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery.[3][4]
戊二烯基焦磷酸是HMG-CoA还原酶途径中的中间产物，直接来自于法尼酰基焦磷酸，用于萜类和萜类化合物的生物合成。[1] 它还作为底物参与了多种重要细胞内蛋白质的预酰化，包括小GTP酶。[2] 这种翻译后修饰对蛋白质定位到细胞内膜以获得正确的功能性是必要的，并成为抗癌药物发现的焦点。[3][4]
Reference:
[1]. Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).
[2]. McTaggart, S.J. Isoprenylated proteins. Cell Mol.Life Sci. 63(3), 255-267 (2006).
[3]. Baron, R.A., and Seabra, M.C. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochemistry Journal 415(1), 67-75 (2008).
[4]. Maynor, M., Scott, S.A., Rickert, E.L., et al. Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Bioorganic & Medicinal Chemistry Letters 18(6), 1889-1892 (2008).