Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].
Gentamicin C1a 抑制 Escherichia coli,P. aeruginosa 和 S. aureus 活性，IC50 值为 1 mg/mL[2]。
Gentamicin C1a (2 mM, 48 h) 对 OC-k3 细胞活力没有影响[2].
Gentamicin C1a (4 mg/kg，静脉推注剂量，单次) 在比格犬体内的平均停留时间为 84 分钟，CL 值为 1.81 mL/min/kg[3]。
[1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7.
[2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410.
[3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7.