Gentisuric acid has the molecular formula C₉H₉NO₅, a molecular weight of 211.17, and its chemical name is N-(2,5-dihydroxybenzoyl) glycine[1]. Gentisuric acid is a metabolite of salicylic acid or aspirin and serves as a substrate for α-amidomonooxygenase (PAM), Gentisuric acid has the ability to alleviate DNA damage induced by mitomycin C[2]。As a derivative of uric acid, gentisuric acid plays an important role in purine metabolism and is often used to study its potential therapeutic effects on gout and other diseases related to uric acid levels [3]。
References:
[1] DeBlassio JL, deLong MA, Glufke U, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383(1):46-55.
[2] Niikawa M, Shin S, Nagase H. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61(2-3):113-9.
[3] Wilson JT, Howell RL, Holladay MW, et al. Gentisuric acid: metabolic formation in animals and identification as a metabolite of aspirin in man. Clin Pharmacol Ther. 1978 Jun;23(6):635-43.
Gentisuric acid的分子式为 C₉H₉NO₅，分子量为 211.17，化学名为N-(2,5-二羟基苯甲酰基)甘氨酸[1]。Gentisuric acid 是一种水杨酸或阿司匹林代谢产物，是α-酰胺单加氧酶（PAM）的底物，能够减轻丝裂霉素C诱导的DNA损伤[2]。Gentisuric acid作为一种尿酸衍生物，Gentisuric acid 在嘌呤代谢中具有重要作用，常被用于研究其对痛风和其他与尿酸水平相关的疾病的潜在治疗效果[3]。