GlpBio

Taurohyocholic Acid

目录号: GC45574纯度: >95.00%同义词: 牛磺胆酸,Tauro-γ-muricholic Acid
Taurohyocholic Acid是一种由猪胆酸衍生的结合牛磺酸的胆汁酸，主要存在于猪胆汁中。
Taurohyocholic Acid
Cas No.: 32747-07-2
规格价格库存数量操作
5mg¥1,217.00现货
1
10mg¥2,187.00现货
1
25mg¥4,855.00现货
1
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产品描述 Description

Taurohyocholic Acid is a taurine-conjugated bile acid derived from hyocholic acid, predominantly found in pig bile[1]. Taurohyocholic Acid plays a crucial role in glucose homeostasis[2] and metabolic regulation[3]. It is also used in research of oncology[4] and end-stage renal disease (ESRD)[5] as a biomarker for predicting treatment efficacy.

Taurohyocholic Acid stimulate GLP-1 production and secretion in intestinal enteroendocrine STC-1 and NCI-H716 cells by promoting proglucagon transcription. In STC-1 and NCI-H716 cells, treatment with 25µM Taurohyocholic Acid for 1 hour significantly increased GLP-1 secretion, and a 24-hour incubation further promoted proglucagon transcription and GLP-1 production[6].

References:
[1]. Fang W, Wen X, Meng Q, et al. Alteration in bile acids profile in Large White pigs during chronic heat exposure. J Therm Biol. 2019 Aug;84:375-383. doi: 10.1016/j.jtherbio.2019.07.027. Epub 2019 Jul 26. PMID: 31466777.
[2]. Cheng Z, Liu G, Zhang X, et al. Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model. Med Sci Monit. 2018 Oct 9;24:7206-7212. doi: 10.12659/MSM.912429. PMID: 30298865; PMCID: PMC6192455.
[3]. Zheng X, Chen T, Zhao A, et al. Hyocholic acid species as novel biomarkers for metabolic disorders. Nat Commun. 2021 Mar 5;12(1):1487. doi: 10.1038/s41467-021-21744-w. PMID: 33674561; PMCID: PMC7935989.
[4]. Chen Y, Wang Y, Lei J, et al. Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma. Front Pharmacol. 2024 Feb 23;15:1364924. doi: 10.3389/fphar.2024.1364924. PMID: 38464731; PMCID: PMC10920247.
[5]. Chen WY, Zhang JH, Chen LL, et al. Bioactive metabolites: a clue to the link between MASLD and CKD? Clin Mol Hepatol. 2024 Oct 21. doi: 10.3350/cmh.2024.0782. Epub ahead of print. PMID: 39428978.
[6]. Zheng X, Chen T, Jiang R, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7. doi: 10.1016/j.cmet.2020.11.017. Epub 2020 Dec 17. PMID: 33338411.

Taurohyocholic Acid是一种由猪胆酸衍生的结合牛磺酸的胆汁酸，主要存在于猪胆汁中[1]。Taurohyocholic Acid在维持血糖稳态[2]和代谢调节[3]中起关键作用。在肿瘤学[4]和终末期肾病（ESRD）[5] 研究中，Taurohyocholic Acid可以作为预测治疗效果的生物标志物。

Taurohyocholic Acid可以通过促进前胰高血糖素转录，刺激STC-1和NCI-H716细胞中GLP-1的生成和分泌。在STC-1和NCI-H716细胞中，用25µM的Taurohyocholic Acid处理1小时可以显著增加GLP-1分泌，24小时的孵育进一步促进了前胰高血糖素转录和GLP-1的生成[6]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

STC-1

Preparation Method

The STC-1 cell were plated into 24 well-plates with an initial cell density of 2*105 cells/well, treated with 25µM Taurohyocholic Acid for 1h. The cell media was removed from the cells, centrifuged at 2,000g for 10min to remove cell debris and the supernatant was collected. An GLP-1 ELISA kit was used to measure GLP-1.

Reaction Conditions

25µM, 1h

Applications

Taurohyocholic Acid can upregulated GLP-1 secretion in STC-1 cells.

References:
[1]. Zheng X, Chen T, Jiang R, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7. doi: 10.1016/j.cmet.2020.11.017. Epub 2020 Dec 17. PMID: 33338411.

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

CAS 号
32747-07-2
同义词
牛磺胆酸,Tauro-γ-muricholic Acid
化学名
2-[[(3α,5β,6α,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(O)(=O)=O)=O)([H])C1
分子式
C26H45NO7S
分子量
515.7 g/mol
溶解性
20mg/mL in ethanol, or DMSO, 30mg/mL in DMF
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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g/mol