Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42 .1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4
References
1. Syme, C.D., Nadal, R.C., Rigby, S.E., et al. Copper binding to the amyloid-beta (Aβ) peptide associated with Alzheimer's disease. Folding, coordination geometry, pH dependence, stoichiometry, and affinity of Aβ(1-28): Insights from a range of complementary spectroscopic techniques. J. Biol. Chem. 279(18), 18169-18177 (2004).
2. Kirschner, D.A., Inouye, H., Duffy, L.K., et al. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84(19), 6953-6957 (1987).
3. Burdick, D., Soreghan, B., Kwon, M., et al. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267(1), 546-554 (1992).
4. Alvarez, X.A., Miguel-Hidalgo, J.J., FernÁndez-Novoa, L., et al. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats. Methods Find. Exp. Clin. Pharmacol. 19(7), 471-479 (1997).