5-Chlorouracil
5-Chlorouracil
请按顺序加入助溶剂，进行下一步前需保证溶液澄清；可采用涡旋、超声或 60°C 水浴助溶。
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy.
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.3,4
References
| On Sale | 1 |
|---|---|
| Cas No. | 1820-81-1 |
| 分子量 | 146.5 |
| 分子式 | C4H3ClN2O2 |
| 别名 | 5-氯尿嘧啶 |
| 溶解度 | DMF: 8 mg/ml,DMSO: 0.8 mg/ml,Ethanol: 53 mg/ml,PBS (pH 7.2): 60 mg/ml |
| 储存条件 | Store at -20°C |
| Canonical SMILES | O=C1NC(NC=C1Cl)=O |
| Canonical SMILES | O=C1NC(NC=C1Cl)=O |