Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.1,2,3,4,5 It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 ?M.2 Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 ?M.3 It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 ?M), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 ?g/ml, respectively).4,5 Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.5
1.Bhakuni, D.S., Tewari, S., and Dhar, M.M.Aporphine alkaloids of Annona squamosaPhytochemistry11(5)1819-1822(1972) 2.Zhao, Y.-Q., Li, G.-R., Zhang, D.-Z., et al.Effects of isocorydine on action potentials in isolated canine purkinje fibers and ventricular musclesJ. Mol. Cell. Cardiol.12(4)324-327(1991) 3.Jiang, Q.-S., Huang, X.-N., Sun, A.-S., et al.Relation of vasodilative action of isocorydine to cyclic nucleotidesChi. J. Pharm. Toxicol.15(4)251-255(2011) 4.Zhong, M., Liu, Y., Liu, J., et al.Isocorydine derivatives and their anticancer activitiesMolecules19(8)12099-12115(2014) 5.Pan, J.-X., Chen, G., Li, J.-J., et al.Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinomaAm. J. Cancer Res.8(1)154-164(2018)