Dihydroresveratrol is a polyketide synthase-derived bibenzyl that has been found in C. sativa and has diverse biological activities.1,2,3,4 It is also an active metabolite of resveratrol that is formed by gut microbiota.5 Dihydroresveratrol inhibits DNA polymerase α but not DNA polymerase δ (Kis =29.3 and >100 ?M, respectively) and the formation of thiobarbituric acid reactive substances (TBARS) in rat liver microsomes (EC50 = 1.57 ?M).2 It stimulates the proliferation of hormone-sensitive MCF-7 breast cancer cells but not hormone-resistant MDA-MB-231 and BT474 breast cancer cells when used at concentrations ranging from 0.01 pM to 100 nM.3 Dihydroresveratrol decreases interalveolar septal thickness and alveolar hemorrhage in a rat model of lung injury induced by cerulein- and LPS-stimulated pancreatitis when administered at a dose of 50 mg/kg.4
1.Boddington, K.F., Soubeyrand, E., Van Gelder, K., et al.Bibenzyl synthesis in Cannabis sativa L.Plant J.109(3)693-707(2022) 2.Stivala, L.A., Savio, M., Carafoli, F., et al.Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrolJ. Biol. Chem.276(25)22586-22594(2001) 3.Gakh, A.A., Anisimova, N.Y., Kiselevsky, M.V., et al.Dihydro-resveratrol—A potent dietary polyphenolBioorg. Med. Chem. Lett.20(20)6149-6151(2010) 4.Lin, Z.-S., Ku, C.F., Guan, Y.-F., et al.Dihydro-resveratrol ameliorates lung injury in rats with cerulein-induced acute pancreatitisPhytother. Res.30(4)663-670(2016) 5.Bode, L.M., Bunzel, B., Huch, M., et al.In vivo and in vitro metabolism of trans-resveratrol by human gut microbiotaAm. J. Clin. Nutr.97(2)295-309(2013)