Emodin 8-glucoside is an anthraquinone glycoside that has been found in R. japonica and has diverse biological activities.1,2,3,4 It inhibits the activities of rat lens aldose reductase and human DNA topoisomerase II (IC50s = 14.4 and 66 μM, respectively, in cell-free assays).1,2 Emodin 8-glucoside (1 ng/ml) promotes the proliferation and differentiation of mouse MC3T3-E1 osteoblastic cells.3 It also decreases infarct size in a rat model of focal cerebral ischemia and reperfusion injury when administered at a dose of 5 mg/kg.4
1.Kim, J.M., Jamg, D.S., Lee, Y.M., et al.Constituents of the fruits of Rumex japonicus with inhibitory activity on aldose reductaseJ. Appl. Biol. Chem.51(1)13-16(2008) 2.Hwangbo, K., Zheng, M.S., Kim, Y.-J., et al.Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonicaArch. Pharm. Res.35(9)1583-1589(2012) 3.Xiang, M.-X., Xu, Z., Su, H.-W., et al.Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cellsMolecules16(1)728-737(2011) 4.Wang, C., Zhang, D., Ma, H., et al.Neuroprotective effects of emodin-8-O-β-D-glucoside in vivo and in vitroEur. J. Pharmacol.577(1-3)58-63(2007)