Cefotetan is a cephamycin antibiotic that is active against both Gram-positive and Gram-negative bacteria including isolates of E. coli, S. aureus, K. pneumoniae, and P. maltophilia (MICs = 0.03-32 mg/ml).1 It reduces mortality by 50% in a rabbit model of fecal peritonitis when administered at a dose of 25 mg/kg twice daily.2 Formulations containing cefotetan have been used in the treatment of various bacterial infections.
1.Daschner, F.D., Goerke, C., Bassler, M., et al.In vitro comparison of cefotetan with five other cephalosporins against nosocomial pathogensChemotherapy28(5)351-354(1982) 2.Ablan, C.J., Olen, R.N., Dobrin, P.B., et al.Efficacy of intraperitoneal antibiotics in the treatment of severe fecal peritonitisAm. J. Surg.162(5)453-456(1991)