Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.1 It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 ?M. Fuziline (0.5 ?M) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol in H9c2 rat cardiomyocytes.2 In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.
1.Xiong, L., Peng, C., Xie, X.-F., et al.Alkaloids isolated from the lateral root of Aconitum carmichaeliiMolecules17(8)9939-9946(2012) 2.Fan, C.-L., Yao, Z.-H., Ye, M.-N., et al.Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathwayJ. Cell Mol. Med.24(2)1332-1344(2020)