α-Tocopherol phosphate
(Synonyms: α-生育酚磷酸盐; alpha-Tocopherol phosphate; TocP; vitamin E phosphate) 目录号 : GC37980
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α-Tocopherol phosphate是一种水溶性的α-生育酚。α-Tocopherol phosphate可通过清除活性氧抑制和调节基因表达发挥功能。
Cas No.:38976-17-9
Sample solution is provided at 25 µL, 10mM.
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α-Tocopherol phosphate is a water-soluble form of α-tocopherol. α-Tocopherol phosphate functions by scavenging reactive oxygen species and regulating gene expression. α-Tocopherol phosphate can also inhibit tumor cell proliferation and induce apoptosis by modulating the activity of signaling pathways such as Hedgehog, PI3K/Akt, and Src/STAT3[1-2]. α-Tocopherol phosphate can be used in research related to antioxidation and cardiovascular diseases[3-4].
In vitro, ALDH+ MDA-MB-231 cells were co-treated with α-Tocopherol phosphate (100μM) and PS-T for 24 hours. α-Tocopherol phosphate reversed the PS-T-induced increase in lipid oxidation and malondialdehyde concentration, and prevented the inhibitory effects of PS-T on colony formation and mammosphere formation[5]. U87MG and U251 glioblastoma cells were treated with α-Tocopherol phosphate (5μM) and ferrostatin-1 for 24 hours. α-Tocopherol phosphate blocked the NKAP knockdown-induced slowdown in cell proliferation and reversed the increased cell death, apoptosis rate, and lactate dehydrogenase release caused by NKAP knockdown[6].
In vivo, SKG/Jcl mice with laminarin-induced rheumatoid arthritis were intraperitoneally administered α-Tocopherol phosphate (100mg/kg; three times a week for 7 weeks). α-Tocopherol phosphate suppressed edema in the paws and joints, improved the arthritis score, and inhibited pannus formation[7]. Male Swiss mice received a single intracerebroventricular injection of α-Tocopherol phosphate (0.1 or 1nmol/site; 3μL). Two days after the injection, α-Tocopherol phosphate reduced the expression of glutathione reductase and peroxiredoxin 2, and decreased glutathione reductase activity in the hippocampus and cerebral cortex[8].
References:
[1] Saleh MM, Lawrence KP, Jones SA, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400.
[2] Wu Z, Zheng X, Meng L, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.
[3] Li X, Liao XQ, Chen WR, et al. Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells. Pharmacol Res Perspect. 2026 Feb;14(1):e70213.
[4] Nishio K, Ishida N, Saito Y, et al. α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse. Free Radic Biol Med. 2011 Jun 15;50(12):1794-800.
[5] Zhou L, Wu Z, Luo K, et al. Polysaccharides from Huaier induce autophagy-dependent ferroptosis to inhibit breast cancer stem cells in triple-negative breast cancer. Cancer Cell Int. 2025 Dec 10;26(1):13.
[6] Sun S, Gao T, Pang B, et al. RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner. Cell Death Dis. 2022 Jan 21;13(1):73.
[7] Hama S, Kirimura N, Obara A, et al. Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice. Molecules. 2022 Feb 20;27(4):1425.
[8] Uchoa MF, de Souza LF, Dos Santos, et al. Modulation of Brain Glutathione Reductase and Peroxiredoxin 2 by α-Tocopheryl Phosphate. Cell Mol Neurobiol. 2016 Aug;36(6):1015-1022.
α-Tocopherol phosphate是一种水溶性的α-生育酚。α-Tocopherol phosphate可通过清除活性氧抑制和调节基因表达发挥功能。α-Tocopherol phosphate还可通过调节Hedgehog、PI3K/Akt和Src/STAT3等信号通路活性来抑制肿瘤细胞增殖并诱导细胞凋亡[1-2]。α-Tocopherol phosphate可用于抗氧化和心血管疾病等相关研究[3-4]。
在体外，α-Tocopherol phosphate（100μM）与PS-T共处理ALDH+ MDA-MB-231细胞24小时。α-Tocopherol phosphate逆转了PS-T诱导的脂质氧化和丙二醛浓度升高，同时阻止了PS-T对细胞集落能力及乳腺球形成的抑制作用[5]。α-Tocopherol phosphate（5μM）与ferrostatin-1处理U87MG和U251胶质母细胞瘤细胞24小时。α-Tocopherol phosphate阻断了由NKAP敲低引起的细胞增殖减缓，同时逆转了NKAP敲低导致的细胞死亡、凋亡率增加和乳酸脱氢酶释放[6]。
在体内，α-Tocopherol phosphate（100mg/kg）每周三次腹腔注射于laminarin诱导的类风湿关节炎模型SKG/Jcl小鼠，连续7周。α-Tocopherol phosphate抑制了足部和关节的水肿，改善了关节炎评分，并抑制了血管翳的形成[7]。α-Tocopherol phosphate（0.1或1nmol/site；3μl）单次脑室注射于雄性Swiss小鼠。注射两天后，α-Tocopherol phosphate降低了海马体和大脑皮层中谷胱甘肽还原酶和过氧还蛋白2的表达，并降低了谷胱甘肽还原酶的活性[8]。
| Cell experiment [1]: | |
Cell lines | ALDH+ MDA-MB-231 cells (triple-negative breast cancer stem cell-enriched population) |
Preparation Method | ALDH+ MDA-MB-231 cells were co-treated with α-Tocopherol phosphate (100μM) and PS-T. The ALDH+ cells were sorted and maintained in culture. |
Reaction Conditions | 100μM; 24 hours. |
Applications | α-Tocopherol phosphate reversed the PS-T-induced increase in lipid oxidation and malondialdehyde concentration. α-Tocopherol phosphate also prevented the inhibitory effects of PS-T on stemness markers (POU5F1, SOX2, NANOG), as well as colony and mammosphere formation. |
| Animal experiment [2]: | |
Animal models | SKG/Jcl mice (laminarin-induced rheumatoid arthritis model) |
Preparation Method | Laminarin dissolved in PBS was intraperitoneally administered to mice to induce arthritis. Seven days after laminarin administration, α-Tocopherol phosphate (100mg/kg) dissolved in PBS was intraperitoneally administered to the mice. Control group received PBS only. |
Dosage form | 100mg/kg; intraperitoneal injection; 3 times a week for 7 weeks. |
Applications | α-Tocopherol phosphate administration ameliorated the edema of the foot and joint, improved the arthritis score, and inhibited pannus formation. |
| Cas No. | 38976-17-9 | SDF | |
| 别名 | α-生育酚磷酸盐; alpha-Tocopherol phosphate; TocP; vitamin E phosphate | ||
| Canonical SMILES | CC1=C(O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CC2)C2=C(C)C(OP(O)(O)=O)=C1C | ||
| 分子式 | C29H51O5P | 分子量 | 510.69 |
| 溶解度 | DMSO: ≥ 100 mg/mL (195.81 mM); Water: < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9581 mL | 9.7907 mL | 19.5814 mL |
| 5 mM | 391.6 μL | 1.9581 mL | 3.9163 mL |
| 10 mM | 195.8 μL | 979.1 μL | 1.9581 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
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2.
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Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
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