3-Acetylursolic acid is a triterpene and derivative of ursolic acid with diverse biological activities.1,2,3 It inhibits ADP-, thrombin-, or epinephrine-induced aggregation of isolated rat platelets (IC50s = <1, 0.8, and <1 mg/ml, respectively).1 3-Acetylursolic acid is active against P. falciparum in vitro (IC50 = 4 ?M).2 It is also active against B. cereus, S. aureus, and S. pneumoniae (MICs = 39.1, 19.6, and 4.81 ?M, respectively).3 It is cytotoxic to HepG2 cells (LC50 = 351 ?M).
1.Habila, J.D., Shode, F.O., and Opoku, A.R.Triterpenoids from Eucalyptus grandis hill ex maiden inhibits platelet aggregationAfr. J. Microbiol. Res.5(26)4646-4651(2011) 2.Innocente, A.M., Silva, G.N.S., Cruz, L.N., et al.Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analoguesMolecules17(10)12003-12014(2012) 3.Setzer, W.N., Setzer, M.C., Bates, R.B., et al.Biologically active triterpenoids of Syncarpia glomulifera bark extract from Paluma, North Queensland, AustraliaPlanta Med.66(2)176-177(2000)