Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.1,2,3 It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 ?M, respectively).1 Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).2 It reduces ear edema induced by arachidonic acid or phorbol 12-myristate 13-acetate in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.3
1.Guzmán, L., Villalón, K., Marchant, M.J., et al.In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agentsSci. Rep.10(1)10534(2020) 2.Arrau, S., Delporte, C., Cartagena, C., et al.Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in miceJ. Ethnaopharmacol.133(1)164-167(2011) 3.Rodríguez-Díaz, M., Delporte, C., Cartagena, C., et al.Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivativesJ. Pharm. Pharmacol.63(5)718-724(2011)