Paricalcitol-D6

目录号: GC36854纯度: >99.50%同义词: 帕立骨化醇 d6
Paricalcitol-D6是Paricalcitol(Zemplar)的氘化形式,能作用于慢性肾衰竭相关的继发性甲状旁腺机能亢进。

Paricalcitol-D6
Cas No.: 2070009-67-3
规格价格库存数量操作
1mg¥4,185.00现货
1
5mg¥20,088.00现货
1
10mg¥33,480.00现货
1
50mg¥0.01现货
1
100mg¥0.01现货
1

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产品描述 Description

Paricalcitol-D6 is the deuterated form of Paricalcitol(Zemplar), which is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. IC50 value:Target: Vd analogChemically, it is 19-nor-1,25-(OH)2-vitamin D2 or 19-nor-1,25-dihydroxyvitamin D2, being an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D2.

[1]. Martinez-Moreno JM, Mu•oz-Casta•eda JR, Herencia C, Montes de Oca A, Estepa JC, Canalejo R, Rodriguez-Ortiz ME, Perez-Martinez P, Aguilera-Tejero E, Canalejo A, Rodriguez M, Almaden Y.In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation.Am J Physiol Renal Physiol. 2012 Aug 8. [2]. Ari E, Kedrah AE, Alahdab Y, Bulut G, Eren Z, Baytekin O, Odabasi D.Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model.Br J Radiol. 2012 Aug;85(1016):1038-43. [3]. Meems LM, Cannon MV, Mahmud H, Voors AA, van Gilst WH, SilljÉ HH, Ruifrok WP, de Boer RA.The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload.J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289. [4]. Blanco-GarcÍa R, Bravo-LÓpez JJ, Moreiras-Plaza M, NÁjera-de la Garza W, Cossio-Annibar C, Beato-Coo L, RodrÍguez-Goyanes G.Microalbuminuria, another use for paricalcitol• Our experience in advanced chronic kidney disease.Nefrologia. 2012 May 14;32(3):401-2. doi: 10.3265/Nefrologia.pre2012.Feb.11378. [5]. Piao SG, Song JC, Lim SW, Chung BH, Choi BS, Yang CW.Protective effect of paricalcitol on cyclosporine-induced renal injury in rats.Transplant Proc. 2012 Apr;44(3):642-5.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
2070009-67-3
同义词
帕立骨化醇 d6
SMILES
C[C@]([C@@H]([C@@H](/C=C/[C@@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])O)C)C)CC1)(CCC/2)[C@@]1(C2=C\C=C3C[C@H](C[C@@H](C/3)O)O)[H]
分子式
C27H38D6O3
分子量
422.67 g/mol
溶解性
DMSO : 100 mg/mL (236.59 mM; Need ultrasonic); DMSO : 100 mg/mL (236.59 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol