Omadacycline is an aminomethylcycline antibiotic.1 It is active against tetracycline-susceptible and -resistant strains of S. aureus, E. faecalis, E. faecium, S. pneumoniae, and E. coli, as well as β-hemolytic streptococci (MICs = ≤0.06-2 ?g/ml). Omadacycline increases survival in mouse models of systemic infection with tetracycline-sensitive and -resistant strains of S. pneumoniae, S. aureus, or E. coli (ED50s = 0.3-3.34 mg/kg). Formulations containing omadacycline have been used in the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI).
1.Macone, A.B., Caruso, B.K., Leahy, R.G., et al.In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcyclineAntimicrob. Agents Chemother.58(2)1127-1135(2014)