Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties.1,2,3 It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml.2 Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml).3 Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.1
1.Paiva, L.A.F., Gurgel, L.A., Silva, R.M., et al.Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffi on acetic acid-induced colitis in ratsVascul. Pharmacol.39(6)303-307(2003) 2.Henry, G.E., Adams, L.S., Rosales, J.C., et al.Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitroCancer Lett.244(2)190-194(2006) 3.Soares, A.C.F., Matos, P.M., Dias, H.J., et al.Variability of the antibacterial potential among analogue diterpenes against Gram-positive bacteria: Considerations on structure-activity subjectCan. J. Chem.97(7)568-575(2019)