Iristectorin B is a natural isoflavone from Iris tectorum with anticancer effects [1]. Iristectorin B can exert anti-inflammatory activity by inhibiting the production of NO induced by lipopolysaccharide (LPS)[2]. Iristectorin B is widely used as an internal reference to develop ionic liquid ultrasonic-assisted extraction methods for the extraction and separation of related compounds[3].
In vitro, Iristectorin B (25µM) treatment for 24 hours significantly enhanced the survival of PC12 cells after glucose oxygen deprivation/reoxygenation (OGD/R) treatment, reduced cell apoptosis, and significantly decreased the expressions of TFR1, HMOX1, and SLC3A2[4].
References:
[1] Ruan L J, Yan B X, Wu Y Q, et al. Integrated Chemometric and Spectrum-effect analysis discriminates Belamcanda chinensis and Iris tectorum in treating A549 lung Cancer cells[J]. Journal of Chromatography B, 2025: 124875.
[2] Gao B, Ma Y, Zhang L, et al. Identification and characterization of the chemical components of Iris tectorum Maxim. and evaluation of their nitric oxide inhibitory activity[J]. Rapid communications in mass spectrometry, 2021, 35(1): e8959.
[3] Sun Y, Li W, Wang J. Ionic liquid based ultrasonic assisted extraction of isoflavones from Iris tectorum Maxim and subsequently separation and purification by high-speed counter-current chromatography[J]. Journal of Chromatography B, 2011, 879(13-14): 975-980.
[4] Zheng M, Zhou M, Lu T, et al. TMT and PRM Based Quantitative Proteomics to Explore the Protective Role and Mechanism of Iristectorin B in Stroke[J]. International Journal of Molecular Sciences, 2023, 24(20): 15195.
Iristectorin B是从Iris tectorum中提取的一种天然异黄酮，具有抗癌作用[1]。Iristectorin B可通过抑制脂多糖（LPS）诱导的一氧化氮产生来发挥抗炎活性[2]。Iristectorin B被广泛用作内参，以开发离子液体超声辅助提取方法，用于相关化合物的提取和分离[3]。
在体外，使用25µM的Iristectorin B处理PC12细胞24小时，显著增强了细胞在糖氧剥夺/复氧（OGD/R）处理后的存活率，减少了细胞凋亡，并显著降低了TFR1、HMOX1和SLC3A2的表达[4]。