Ganoderic acid H is a triterpene that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits angiotensin-converting enzyme (ACE; IC50 = 26 ?M).1 Ganoderic acid H also inhibits HIV-1 protease with an IC50 value of 200 ?M.2 It reduces colony formation and migration of MDA-MB-231 breast cancer cells in a concentration-dependent manner.3 In vivo, ganoderic acid H (1, 3, and 5 mg/kg) inhibits acetic acid-induced writhing in mice.4
1.Morigiwa, A., Kitabatake, K., Fujimoto, Y., et al.Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidumChem. Pharm. Bull. (Tokyo)34(7)3025-3028(1986) 2.El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al.Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidumPhytochemistry49(6)1651-1657(1998) 3.Jiang, J., Grieb, B., Thyagarajan, A., et al.Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-κB signalingInt. J. Mol. Med.21(5)577-584(2008) 4.Koyama, K., Imaizumi, T., Akiba, M., et al.Antinociceptive components of Ganoderma lucidumPlanta Med.63(3)224-227(1997)