Ganoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities.1,2,3 It is an inhibitor of β-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes).2 Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 ?g/ml.3
1.Komoda, Y., Nakamura, H., Ishihara, S., et al.Structures of new terpenoid constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae)Chem. Pharm. Bull.33(11)4829-4835(1985) 2.Kim, D.-H., Shim, S.-B., Kim, N.-J., et al.β-Glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidumBiol. Pharm. Bull.22(2)162-164(1999) 3.Fatmawati, S., Shimizu, K., and Kondo, R.Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidumPlanta Med.76(15)1691-1693(2010)