GlpBio

gamma-Secretase Modulators

目录号: GC36110纯度: >99.50%同义词: (E)-(4R,9AS)-7-[3-甲氧基-4-(4-甲基-1H-咪唑-1-基)苯亚甲基]-4-(3,4,5-三氟苯基六氢吡啶并[2,1-C][1,4]嗪-6-酮,Amyloid-β production inhibitor; γ-Secretase Modulators
gamma-Secretase Modulators (Amyloid-β production inhibitor)是淀粉状蛋白β生成抑制剂，可作用于阿尔茨海默病。
gamma-Secretase Modulators
Cas No.: 937812-80-1
规格价格库存数量操作
5mg¥4,210.00现货
1
10mg¥8,169.00现货
1
50mg¥0.01现货
1
100mg¥0.01现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease.IC50 value:Target: γ-secretase modulator

[1]. Watahiki H, Yagishita S, Futai E, Ishiura S.CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.Neurosci Lett. 2012 Sep 27;526(2):96-9. Epub 2012 Aug 23. [2]. Wanngren J, Ottervald J, Parpal S, Portelius E, Str•mberg K, Borgeg•rd T, Klintenberg R, JurÉus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlstr•m H.Second generation γ-secretase modulators exhibit different modulation of Notch β [3]. Wagner SL, Tanzi RE, Mobley WC, Galasko D.Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease.Arch Neurol. 2012 Jul 16:1-4. [4]. Bulic B, Ness J, Hahn S, Rennhack A, Jumpertz T, Weggen S.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease.Curr Neuropharmacol. 2011 Dec;9(4):598-622. [5]. Kretner, Benedikt; Fukumori, Akio; Gutsmiedl, Amelie; Page, Richard M.; Luebbers, Thomas; Galley, Guido; Baumann, Karlheinz; Haass, Christian; Steiner, Harald. Attenuated A.beta.42 Responses to Low Potency .gamma.-Secretase Modulators Can Be Overcome for

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
937812-80-1
同义词
(E)-(4R,9AS)-7-[3-甲氧基-4-(4-甲基-1H-咪唑-1-基)苯亚甲基]-4-(3,4,5-三氟苯基六氢吡啶并[2,1-C][1,4]嗪-6-酮,Amyloid-β production inhibitor; γ-Secretase Modulators
SMILES
O=C1N2[C@@H](COC[C@]2([H])CC/C1=C\C3=CC(OC)=C(C=C3)N4C=NC(C)=C4)C5=CC(F)=C(F)C(F)=C5
分子式
C26H24F3N3O3
分子量
483.48 g/mol
溶解性
DMSO: ≥ 100 mg/mL (206.83 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol