Corydine is an aporphine alkaloid that has been found in Corydalis and has diverse biological activities.1,2,3 It inhibits the proliferation of murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells when used at concentrations ranging from 10 to 100 ?g/ml.1 Corydine binds to μ-opioid receptors (Ki = 2.82 ?M) and induces [35S]GTPγS binding in CHO cells expressing human μ-opioid receptors (EC50 = 0.51 ?M).2 It also is active against L. donovani promastigotes (IC50 = 26.7 ?M).3
1.Kondo, Y., Imai, Y., Hojo, H., et al.Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphineJ. Pharmacobiodyn.13(7)426-431(1990) 2.Kaserer, T., Steinacher, T., Kainhofer, R., et al.Identifcation and characterization of plant?derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonistsSci. Rep.10(1)13804(2020) 3.del Rayo Camacho, M., Kirby, G.C., Warhurst, D.C., et al.Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activitiesPlanta Med.66(5)478-480(2000)