Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration[1].
[1]. Subehan, et al. Phytochemical investigation of the active constituents from Caesalpinia sappan on stimulation of osteoblastic cells. Plant Biotechnology, 2014,31(5), 505-509.