GlpBio

ATP-polyamine-biotin

目录号: GC35422纯度: >97.00%同义词: ATP多胺生物素
ATP-polyamine-biotin 是一种细胞渗透性的有效激酶底物, 与其他已知的ATP类似物具有相似的转换和动力学特性, 细胞毒性EC50值为19 ± 1 nM。
ATP-polyamine-biotin
Cas No.: 1800401-93-7
规格价格库存数量操作
1mg¥3,582.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM.ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.

[1]. Fouda AE, Pflum MK. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9618-21.

产品文档 Product Documents

Purity:>97.00%

化学性质Chemical Properties

CAS 号
1800401-93-7
同义词
ATP多胺生物素
SMILES
O=C(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)NCCCN(C)CCCCN(C)CCCNP(O)(OP(O)(OP(O)(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(N=CN=C5N)=C5N=C4)O3)=O)=O)=O
分子式
C32H58N11O14P3S
分子量
945.85 g/mol
溶解性
Water: 6 mg/mL (6.34 mM and warming)
保存条件
Store at 4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol