4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.1,2,3,4 It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 ?g/ml, respectively).1 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid .2 It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.3 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.4
1.Ryu, S.Y., Choi, S.U., Lee, C.O., et al.Antitumor activity of some phenolic components in plantsArch. Pharm. Res.1742-44(1994) 2.Ko, S.K., Lee, S.M., and Whang, W.K.Anti-platelet aggregation activity of stilbene derivatives from Rheum UndulatumArch. Pharm. Res.22(4)401-403(1999) 3.Kerem, Z., Regev-Shoshani, G., Flaishan, M.A., et al.Resveratrol and two monomethylated stilbenes from Israeli Rumex bucephalophorus and their antioxidant potentialJ. Nat. Prod.66(9)1270-1272(2003) 4.Tran, P.T., Park, D.-H., Kim, O., et al.Desoxyrhapontigenin inhibits RANKL?induced osteoclast formation and prevents inflammation?mediated bone lossInt. J. Mol. Med.42(1)569-578(2018)