10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T. chinensis.1,2 It induces the disassembly of pig brain and Physarum microtubules in cell-free assays (IC50s = 0.3 and 0.5 ?M, respectively).1 10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of (IC50 = 5 ?M), as well as induces cell cycle arrest at the G2/M phase and apoptosis in, PC3 prostate cancer cells.2
1.Lataste, H., Senilh, V., Wright, M., et al.Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubulesProc. Natl. Acad. Sci. USA81(13)4090-4094(1984) 2.Jiang, S., Zu, Y., Fu, Y., et al.Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxelInt. J. Oncol.33(1)103-111(2008)