(R)-Ofloxacin is a fluoroquinolone antibiotic and the (R) isomer of the antibiotics ofloxacin and levofloxacin .1 It is active against certain Gram-positive and Gram-negative bacteria, including E. coli, P. aeruginosa strains 32104 and 32122, S. aureus strains 209P and Smith, and S. epidermis strain 56556 (MICs = 0.78, 12.5, 6.25, 25, 12.5, and 25 ?g/ml, respectively) but not S. epidermis strain 56500, S. pyogenes, or S. faecalis (MICs = >100 ?g/ml for all).2 (R)-Ofloxacin inhibits E. coli DNA gyrase with an IC50 value of 75 ?g/ml, which is approximately 30- and 50-fold lower than inhibition by ofloxacin and levofloxacin, respectively.1
1.Morrissey, I., Hoshino, K., Sato, K., et al.Mechanism of differential activities of ofloxacin enantiomersAntimicrob. Agents Chemother.40(8)1775-1784(1996) 2.Hayakawa, I., Atarashi, S., Yokohama, S., et al.Synthesis and antibacterial activities of optically active ofloxacinAntimicrob. Agents Chemother.29(1)163-164(1986)