(–)-Sinoacutine is an alkaloid that has been found in S. acutum and has cytoprotective and vasorelaxant activities.1,2 It inhibits hydrogen peroxide-induced decreases in viability in PC12 cells when used at concentrations of 1 and 10 μM.1 (–)-Sinoacutine induces relaxation of precontracted isolated rat aortic rings (IC50 = 32.8 μM).2
1.Bao, G.-H., Qin, G.-W., Wang, R., et al.Morphinane alkaloids with cell protective effects from Sinomenium acutumJ. Nat. Prod.68(7)1128-1130(2005) 2.Tsai, T.-H., Wang, G.-J., and Lin, L.-C.Vasorelaxing alkaloids and flavonoids from Cassytha filiformisJ. Nat. Prod.71(2)289-291(2008)