GlpBio

Ganglioside GT1b (bovine) (sodium salt)

目录号: GC52505纯度: >98.00%同义词: Ganglioside G1, Trisialoganglioside GT1b
A sphingolipid
Ganglioside GT1b (bovine) (sodium salt)
规格价格库存数量操作
1 mg¥1,617.00现货
1
5 mg¥5,975.00现货
1
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产品描述 Description

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.1 Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor.2 Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM.3 This product contains ganglioside GT1b molecular species with variable fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1558]

1.Schengrund, C.-L., DasGupta, B.R., and Ringler, N.J.Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereofJ. Neurochem.57(3)1024-1032(1991) 2.Erickson, K.D., Garcea, R.L., and Tsai, B.Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirusJ. Virol.83(19)10275-10279(2009) 3.Kanda, N., and Tamaki, K.Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cellsImmunology96(4)628-633(1999)

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

同义词
Ganglioside G1, Trisialoganglioside GT1b
SMILES
CCCCCCCCCCCCC/C=C/[C@]([H])([C@](NC(CCCCCCCCCCCCCCCCC)=O)([H])CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O[C@@]3(C([O-])=O)O[C@H]([C@@H]([C@H](C3)O)NC(C)=O)[C@H](O)[C@H](O[C@@]4(C([O-])=O)O[C@H]([C@@H]([C@H](C4)O)NC(C)=O)[C@H](O)[C@H](O)CO)CO)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O[C@@]7(C([O-])=O)O[C@H]([C@@H]([C@H](C7)O)NC(C)=O)[C@H](O)[C@H](O)CO)O)CO)NC(C)=O)CO)O)O)O.[Na+].[Na+].[Na+]
分子式
C95H162N5O47 • 3Na (for stearoyl)
分子量
2126.3 g/mol
溶解性
Chloroform:Methanol (2:1): Soluble,Water: micellar aggregates
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol