Ganciclovir-d5 is intended for use as an internal standard for the quantification of ganciclovir by GC- or LC-MS. Ganciclovir is a synthetic analog of 2'-deoxy-guanosine that inhibits the replication of human cytomegalovirus (CMV) with an IC50 value of 0.01 μM.1,2 It is effective against strains of CMV from human, monkey, mouse, and guinea pig.1,2 Formulations containing ganciclovir have been used to treat or prevent CMV infections.3,4
1.Rasmussen, L., Chen, P.T., Mullenax, J.G., et al.Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferonsAntimicrob. Agents Chemother.26(4)441-445(1984) 2.Freitas, V.R., Smee, D.F., Chernow, M., et al.Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesAntimicrob. Agents Chemother.28(2)240-245(1985) 3.Balfour, H.H., Jr.Management of cytomegalovirus disease with antiviral drugsRev.Infect.Dis.12(Suppl. 7)S849-S860(1990) 4.Bean, B.Antiviral therapy: Current concepts and practicesClin.Microbiol.Rev.5(2)146-182(1992)