Gadoteridol is a gadolinium-based MRI contrast agent.1,2 It enhances the visibility of intraparenchymal and meningeal tumors in an orthotopic rat model of brain cancer when administered at a dose of 0.25 mmol/kg.1 In vitro labeling of murine mesenchymal stem cells (MSCs) with gadoteridol and subsequent injection into mice has been used to track their migration to spinal cord injury lesions in vivo.2 Formulations containing gadoteridol have been used to visualize intra- and extracranial lesions in the head, neck, and spine.
1.Runge, V.M., Gelblum, D.Y., and Jacobson, S.Gd HP-DO3A—experimental evaluation in brain and renal MRMagn. Reson. Imaging9(1)79-87(1991) 2.Filippi, M., Boido, M., Pasquino, C., et al.Successful in vivo MRI tracking of MSCs labeled with gadoteridol in a spinal cord Injury experimental modelExp. Neurol.28266-77(2016)