Z-His-OBzl is a derivative of histidine (His) and can mediate the coordination of Mn2+ co-assembly to form peptide-based photosensitive nanomedicines[1]. Z-His-OBzl acts as the template amino acid derivative to induce near-infrared (NIR) cyanine dye indocyanine green (ICG) co-assembly due to the amphiphilic and positively charged nature [2]. Z-His-OBzl regulates the self-assembly of phthalocyanine tetrasulfonic acid (Pc) into nanoparticles without vesicle structures, exhibiting fluorescence quenching in solution [3]. Z-His-OBzl can be combined with the endogenous biological pigment biliverdin (BV) to prepare nanoparticles with wide near-infrared absorption, which act as photoacoustic imaging (PAI) contrast agents for diagnosing tumors with high spatial resolution and penetration depth[4].
References:
[1] Li S, van Hest J C M, Xing R, et al. Peptide self-assembly meets photodynamic therapy: from molecular design to antitumor applications[J]. Chemical Communications, 2025, 61(73): 13841-13851.
[2] Li S, Chang R, Zhao L, et al. Two-photon nanoprobes based on bioorganic nanoarchitectonics with a photo-oxidation enhanced emission mechanism[J]. Nature Communications, 2023, 14(1): 5227.
[3] Han J, Liu K, Chang R, et al. Photooxidase‐mimicking nanovesicles with superior photocatalytic activity and stability based on amphiphilic amino acid and phthalocyanine co‐assembly[J]. Angewandte Chemie, 2019, 131(7): 2022-2026.
[4] Chang R, Zhao L, Xing R, et al. Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications[J]. Chemical Society Reviews, 2023, 52(8): 2688-271
Z-His-OBzl 是一种组氨酸衍生物，可介导Mn2+的配位共组装，形成基于肽的光敏纳米药物[1]。由于具有两亲性和正电荷特性，Z-His-OBzl可作为模板氨基酸衍生物，诱导近红外花菁染料indocyanine green (ICG)共组装[2]。Z-His-OBzl可调控phthalocyanine tetrasulfonic acid (Pc)自组装形成无囊泡结构的纳米颗粒，并在溶液中表现出荧光猝灭[3]。Z-His-OBzl可与内源性生物色biliverdin (BV)结合，制备具有宽近红外吸收的纳米颗粒，这些纳米颗粒可作为光声成像(PAI)造影剂，用于高空间分辨率和穿透深度的肿瘤诊断[4]。