SV40 Nuclear Transport Signal Peptide Analog

NLS, cell-penetrating peptide containing 7 amino acids homologous to the SV40 T antigen, was capable of inducing the transport of several carrier proteins to the nucleus. The terminal cysteine permits the attachment of this peptide to any protein using a heterobifunctional crosslinking reagent. Coupling to plasmid DNA has also been realized by M.G.SebastyÉn and coworkers. Heterodimerization of TAT and NLS yields an even more effective transfecting peptide.