Ophthalmic Acid is an analog of glutathione (GSH) and a marker of oxidative stress and hepatic glutathione depletion. Ophthalmic Acid can inhibit the Glyoxalase I reaction and serve as a biomarker for oxidative stress, while also potentially acting as a neurotransmitter to affect motor control pathways[1-2].
References:
[1] Kaur G, Leslie EM, Tillman H, et al. Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors. PLoS One. 2015 Sep 25;10(9):e0139299.
[2] CLIFFE EE, WALEY SG. The mechanism of the glyoxalase I reaction, and the effect of ophthalmic acid as an inhibitor. Biochem J. 1961 Jun;79(3):475-82.
Ophthalmic Acid 是一种谷胱甘肽（GSH）的类似物，是氧化应激和肝脏谷胱甘肽消耗的标志物。Ophthalmic Acid可抑制Glyoxalase I反应并作为氧化应激生物标志物，同时可能作为神经递质影响运动控制通路[1-2]。