L-Thyronine is a deiodinated thyroid hormone. L-Thyronine is formed by the condensation of two tyrosine residues and is a basic structural molecule of a class of thyroid hormones. L-Thyronine is inactive at rat GABAA receptors with an IC50 greater than 100μM, and is commonly used as a non-iodinated scaffold control in studies of thyroid hormone and its analogues[1].
References:
[1] Martin JV, Padron JM, Newman MA, Chapell R, Leidenheimer NJ, Burke LA. Inhibition of the activity of the native gamma-aminobutyric acid A receptor by metabolites of thyroid hormones: correlations with molecular modeling studies.Brain Res. 2004;1004(1-2):98-107.
L-Thyronine是一种脱碘甲状腺素。L-Thyronine由两个酪氨酸缩合形成，是一类甲状腺激素的基础结构分子。L-Thyronine对大鼠GABAA受体的IC50值大于100μM，是无活性化合物，在甲状腺激素及类似物活性研究中，常作为缺少碘取代的骨架对照[1]。