H-Pro-Tyr-OH is a dipeptide that can be cyclized and is used for membrane analysis[1]. Peptides containing the H-Pro-Tyr-OH fragment have a low-energy conformation and can be used in multiple molecular dynamics simulation experiments[2]. H-Pro-Tyr-OH is widely used as a model compound for analyzing molecular conformation in circular dichroism experiments[3].
References:
[1] Matsufuji H, Matsui T, Ohshige S, et al. Antihypertensive effects of angiotensin fragments in SHR[J]. Bioscience, biotechnology, and biochemistry, 1995, 59(8): 1398-1401.
[2] Nardi F, Kemmink J, Sattler M, et al. The cisproline (i− 1)-aromatic (i) interaction: Folding of the Ala-cisPro-Tyr peptide characterized by NMR and theoretical approaches[J]. Journal of biomolecular NMR, 2000, 17(1): 63-77.
[3] Wierzchowski K L, Majcher K, Poznański J. CD investigations on conformation of HX-(Pro) nY-OH peptides (X= Trp, Tyr; Y= Tyr, Met); models for intramolecular long range electron transfer[J]. Acta Biochimica Polonica, 1995, 42(2): 259-268.
H-Pro-Tyr-OH是一种可环化的二肽，用于膜分析[1]。含有H-Pro-Tyr-OH片段的肽具有低能量构象，可应用于多项分子动力学模拟实验[2]。H-Pro-Tyr-OH被广泛用作圆二色性实验中分析分子构象的模型化合物[3]。