H-Phe-Tyr-OH is a dipeptide composed of two amino acids, L-phenylalanine (Phe) and L-tyrosine (Tyr), with a free amino group at the N-terminus and a free carboxyl group at the C-terminus. H-Phe-Tyr-OH dipeptide can inhibit Angiotensin-Converting Enzyme (ACE) activity and is often used as a drug to treat hypertension, cardiovascular disease and diabetic nephropathy[1]. In spontaneously hypertensive rats, a single oral administration of H-Phe-Tyr-OH at 1mg/kg reduced systolic blood pressure by 16mmHg, while a dose of 10mg/kg reduced systolic blood pressure by 21mmHg[2].
References:
[1] Kecel-Gündüz S, Budama-Kilinc Y, Cakir Koc R, et al. Computational design of Phe-Tyr dipeptide and preparation, characterization, cytotoxicity studies of Phe-Tyr dipeptide loaded PLGA nanoparticles for the treatment of hypertension. J Biomol Struct Dyn. 2018;36(11):2893-2907.
[2] Sato M, Hosokawa T, Yamaguchi T, et al. Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J Agric Food Chem. 2002;50(21):6245-6252.
H-Phe-Tyr-OH是一种二肽，由L-苯丙氨酸（Phe） 和L-酪氨酸（Tyr）两个氨基酸组成，其N端为游离氨基，C端为游离羧基。H-Phe-Tyr-OH二肽能抑制血管紧张素转化酶（ACE）活性，常被用作治疗高血压、心血管疾病和糖尿病肾病的药物[1]。在自发性高血压大鼠（SHR）中，H-Phe-Tyr-OH单次口服给药1mg/kg可使收缩压降低16mmHg，而10mg/kg给药则可使收缩压降低21mmHg[2]。