H-Arg-Phe-OH is a dipeptide that mimics the effects of neuropeptides (such as FMRF‑NH₂) [1]. H‑Arg‑Phe‑OH can activate the sympathetic nervous system through the central nervous system, increase blood pressure and heart rate, and has amphiphilic surface activity and can induce protein native conformation aggregation [2].
References:
[1]. Ewenson A, Laufen R, Chorev M, et al. Dehydro ketomethylene and ketomethylene analogs of substance P: synthesis and biological activity. Journal of medicinal chemistry. 1988 Feb;31(2):416-21.
[2]. Artemova N, Stein-Margolina V, Smirnova E, Gurvits B. Formation of supramolecular structures of a native-like protein in the presence of amphiphilic peptides: Variations in aggregate morphology. FEBS letters. 2012 Jan 20;586(2):186-90.
H-Arg-Phe-OH是一种模拟神经肽（如FMRF-NH₂）作用的二肽 [1]。H-Arg-Phe-OH可通过中枢神经系统激活交感神经系统，升高血压、增心率，且具有两亲性表面活性，能诱导蛋白质天然构象聚集 [2]。